cefotaxime acid from cefotaxime sodium

Cefotaxime Sodium powder for solution for injection, Hikma, 500 mg, vial, 10 count, NDC 00143-9930-10; Reason for the Shortage. Hospira has discontinued Claforan. Sanofi-Aventis manufactured Claforan for Hospira and is no longer making the product. Baxter discontinued Claforan in late-2015. CLAFORAN Hoechst Marion Roussel . Cefotaxime Sodium . Antibiotic . Action And Clinical Pharmacology: Animal studies demonstrate that cefotaxime has no significant effect on the CNS, cardiovascular and respiratory systems, kidneys, blood clotting mechanisms and blood glucose levels. There is a dose-dependent increase in serum levels after i.v. administration of 500 mg, 1 and 2 g of cefotaxime

Showing metabocard for Cefotaxime (HMDB0014636)

General function: Involved in transmembrane transport Specific function: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate

Jan 21, 2016Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of cefotaxime for injection range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 4.5 to 6.5.

The objective of the study was to evaluate comparative efficacy and safety of cefotaxime-sulbactam injection with amoxicillin-clavulanic acid injection in pediatric patients with LRTI. Methods This multicentric, randomized, comparative study enrolled 102 pediatric in-patients diagnosed of pneumonia or bronchopneumonia.

Cefotaxime sodium contains approximately 51 mg (2.2 mEq) per each gram in parenteral form. The frozen solutions of cefotaxime sodium are additionally formulated with sodium hydrate as a buffer. In patients with conditions that may require sodium restriction (such as congestive heart failure, hypertension, and fluid retention), the sodium

Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. It is given either by injection into a vein or muscle.


Cefotaxime Sodium Injection

The bactericidal activity of cefotaxime sodium results from inhibition of cell wall synthesis. Cefotaxime sodium has in vitro activity against a wide range of gram-positive and gram-negative organisms. Cefotaxime sodium has a high degree of stability in the presence of β-lactamases, both penicillinases and cephalosporinases, of gram-negative and gram-positive bacteria.

May 02, 2016Isolates ESBL +ve Ceftazidime Clavulanic acid Cefotaxime Clavulanic acid 500 226(45.2%) 226 (45.2%) 180(36%) Fig.1 Showing Zone Enhancement ( 5 mm) by the use of Cefazidime+ Clavulanic acid (CAC) in omparion to Ceftazidime (CAZ) alone Similarly by using Cefotaxime + Clavulanic acid ( CEC) in Comparion to Cefotaxime

Jun 15, 2017Compound Sodium Lactate Intravenous Infusion BP (Ringer-lactate solution for injection) Intravenous Infusion: 1-2g cefotaxime are dissolved in 40-100ml of infusion fluid. After 24 hours any unused solution should be discarded. Cefotaxime is compatible with 1% Lidocaine Injection BP; however freshly prepared solutions should be used.

Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of Cefotaxime for Injection, USP range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5.

Cefotaxime sodium, a parenteral cephalosporin antibiotic, exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Chemical structure modifications have enabled this compound to be resistant to the action of Richmond I, III, IV, and V beta-lactamase enzymes. Excellent acti

MIC: . 0.1 μg/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. The cephalosporins, a class of β-lactam antibiotics originally derived from the fungus Acremonium, are indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic.

Although there is no clinical evidence supporting the necessity of changing the dosage of cefotaxime sodium in patients with even profound renal dysfunction, it is suggested that, until further data are obtained, the dose of cefotaxime sodium be halved in patients with estimated creatinine clearances of less than 20 mL/min/1.73 m 2.

Sodium content. Each g of cefotaxime sodium contains about 2.09 mmol of sodium. Interactions As for many cephalosporins, probenecid reduces the renal clearance of cefotaxime, resulting in higher and prolonged plasma concentrati ons of cefotaxime and its desacetyl metabolite. Antibacterials. The total body clearance of cefotaxime has

Inside Rx

Cefotaxime es un antibitico cefalosporina. Funciona peleando la bacteria en su cuerpo. La inyeccin de cefotaxime se usa en el tratamiento de diferentes infecciones bacterianas, que incluyen las infecciones agudas o las que atientan contra la vida. Cefotaxime se usa tambin para prevenir infecciones en personas que van a tener una ciruga.

Paratyphoid fever is considered an emerging systemic intracellular infection caused by Salmonella enterica serotypes Paratyphi A, B, and C. We performed in vitro time-kill studies on three clinical isolates of nalidixic acid-resistant Salmonella serotype Paratyphi (NARSP) with different concentrations of ciprofloxacin and cefotaxime to identify combinations of antibiotics with synergistic

MIC: . 0.1 μg/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. The cephalosporins, a class of β-lactam antibiotics originally derived from the fungus Acremonium, are indicated for the prophylaxis and treatment of infections caused by bacteria susceptible to this particular form of antibiotic.

Sodium restriction – cefotaxime contains 48.2 mg/g (2.1 mmol/g) sodium. Drug Interactions Cefotaxime, as do many cephalosporins, may potentiate the renal toxicity of nephrotoxic drugs. Cefotaxime should not be combined with bacteriostatic antibiotics (e.g., tetracycline, erythromycin or chloramphenicol) since an antagonistic effect is possible.

Cefotaxime sodium salt is a third generation semisynthetic cephalosporin antibiotic, which is chemically synthesized form 7-aminocephalosporanic acid (7-ACA) [].It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the first and second generation cephalosporins.

Sep 06, 2017Although there is no clinical evidence supporting the necessity of changing the dosage of cefotaxime sodium in patients with even profound renal dysfunction, it is suggested that, until further data are obtained, the dose of cefotaxime sodium be halved in patients with estimated creatinine clearances of 20 mL/min/1.73 m2.

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